Initiated in 2008 with seed funding from the National Health and Medical Research Council (NHMRC) of South Africa, the SAPCS was established to provide a collaborative research infrastructure for clinical, epidemiological, and molecular-genetic studies aimed at understanding the aetiology of prostate cancer ethnic-based health disparities. In 2022, SAPCS became a co-funded member of HEROIC PCaPH Africa1K. Focused on South Africa and Namibia, SAPCS is managed out of the University of Pretoria, in partnership with the University of Sydney. The management team includes Clinical Director Prof Riana Bornman (University of Pretoria), Scientific Director Prof Vanessa Hayes (University of Sydney) and Urological Director Prof Shingai Mutambirwa (Sefako Makgatho Health Sciences University, South Africa). SAPCS-Namibia is Directed by Dr Hagen E.A. Förtsch (University of Namibia Medical School)